Applied Biocatalysis Symposium

Applied Biocatalysis Symposium

Scientific Program

Applied Biocatalysis 2002

7^th Workshop of the VAAM-Working Group

"Biotransformations"

at the

Inst. of Biotechnology & Inst. of Organic Chemistry

ETH Zurich

Hoenggerberg HCI, G3

8093 Zurich

Switzerland

Zurich, 9^th - 11^th of October 2002

Organisation:

Dr. Andreas Schmid

Prof. Donald Hilvert

Prof. Bernard Witholt

Program (pdf-version)
Wednesday, October 9, 2002

17:00 - 19:30		Registration ETH Hoenggerberg, HCI G3 (New Chemistry Building)

Thursday, October 10, 2002

08:00 - 09:00		Registration
09:00 - 09:20		Andreas Schmid (Inst. of Biotechnology, ETH, Zurich, CH) Welcome Address

Session 1		Screening (Chair: A. Schmid, ETHZ, Biotechnology)

09:20 - 10:00	L 01	Jean Louis Reymond (Univ. Bern, Inst. Of Org. Chemistry, Bern, CH) Enzyme Screening and Fingerprinting
10:00 - 10:25	O 01	Klaus Liebeton (B.R.A.I.N. AG, Zwingenberg, D) New lipolytic enzymes from the metagenome.

10:25 - 11:00		Coffee break


Session 2		Enzyme and Biocatalyst Engineering (Chair: D. Hilvert, ETHZ, Organic Chemistry)

11:00 - 11:40	L 02	Peter Kast (ETH, Inst. of Org. Chemistry, Zurich, CH) Darwinian evolution to probe (and design) enzyme structure and function.
11:40 - 12:05	O 02	Dan S. Tawfik (The Weizmann Institute of Science, Rehovot, Il) Molecular evolution of an extremely fast phospho-triesterase by in vitro compartimentalization (IVC).
12:05 - 12:30	O 03	Willem J.H. van Berkel (Wageningen University, Wageningen, NL) Engineering of flavoprotein oxygenases and oxidases.

12:30 - 13:30		Lunch (individual, at the MENSA Hoenggerberg)

Session 3		Sources of Novel Biocatalysts for Industrial Applications (Chair: S. Panke, ETHZ, Process Engineering)

13:30 -14:10	L 03	Beat Wirz (Roche Pharma, Basel, CH) Biotransformation services in pharmaceutical industry.
14:10 - 14:35	O 04	Thomas Daußmann (Jülich Fine Chemicals, Jülich, D) Alcohol dehydrogenases for the asymmetric synthesis of chiral compounds.
14:35 - 15:00	O 05	Dick B. Janssen (Biochemical Laboratory, University of Groningen, NL) Engineered biocatalysts for the production of semi-synthetic b-lactam antibiotics.

15:00 - 15:20		Coffee break

Session 4		New Products via Biocatalysis (Chair: C. Syldatk, University Stuttgart)

15:20 - 16:00	L 04	Oreste Ghisalba (Novartis, Basel, CH) Chemo-enzymatic synthesis of chiral building blocks and drug metabolites for pharma applications.
16:00 - 16:25	O 06	Rein V. Ulijn (Dep. of Chemistry, University of Eidinburgh, UK) The first examples of protease-catalyzed solid phase peptide synthesis.
16:25 - 16:50	O 07	Wolfgang Zimmermann (Dep. of Bioprocess Technology, University of Chemnitz, D) Enzymes for the synthesis of large-ring cyclodextrins.

17:00 - 19:00		Poster session

20:00 - 23:00		Workshop Dinner @ Lake-Side Casino (shuttle bus service)

Friday, October 11, 2002

Session 5		Biocatalysis at the Chemical Industry (Chair: W. Treffenfeldt, DOW Germany)

09:00 - 09:40	L 05	Bernhard Hauer (BASF AG, Ludwigshafen, D) Enzymes as industrial biocatalysts: strategies for their discovery and improvement
09:40 - 10:05	O 08	Sol M. Resnick (The DOW Chemical Company, San Diego, USA) Enzymatic resolution of chiral P-series glycol ethers.
10:05 - 10:30	O 09	Marco Eissen (Lab. of Technical Chemistry, ETH, Zurich, CH) Concepts towards a sustainable synthesis design using biocatalysts.

10:30 - 10:50		Coffee break

Session 6		New Reactions and Technology (Chair: D. Janssen, University Groningen)

10:50 - 11:30	L 06	Fredi Brühlmann (Firmenich SA, Geneva, CH) Flavour and fragrance chemicals through biocatalysis.
11:30 - 11:55	O 10	Frank Hollmann (Inst. of Biotechnology, ETH, Zurich, CH) Chemo-enzymatic redox reactions using oxidoreductases and organometallic catalysts.
11:55 - 12:20	O 11	Andreas Liese (Inst. of Biotechnology, Research Centre Jülich, Jülich, D) Molecular hydrogen driven efficient generation and regeneration of NADPH.
12:20 - 12:45	O 12	Heiko Feitkenhauer (Lab. of Chemical Engineering and Industrial Chemistry, ETH, Zurich, CH) Cotton finishing with anaerobic cultures - is a complete replacement of auxiliary chemicals and purified enzymes feasible?

12:45 - 13:45		Lunch (individual, at the MENSA Hoenggerberg)

Session 7		Biocatalysis for Fine Chemicals Production (Chair: R. Wohlgemuth, FLUKA AG)

13:45 – 14:25	L 07	Andreas Kiener (LONZA AG, Visp, CH) Biocatalytic approaches for large scale production of synthons.
14:25 - 14:50	O 13	Dongliang Chang (Inst. of Biotechnology, ETH, Zurich, CH) Regio- and stereoselective hydroxylation of non-activated carbon atoms with Sphingomonas sp. HXN-200: synthetic applications.
14:50 - 15:15	O 14	Manfred Zinn (Swiss Federal Institute of Materials Testing and Research, EMPA, Dübendorf, CH) Multiple nutrient limited growth of bacteria as a means to tailor-made polyhydroxyalkanoate.

15:15 - 15:35		Coffee Break

Session 8		Putting Things together: From Enzyme Mechanism to Custom Manufacturing (Chair: A. Schmid, ETHZ, Biotechnology)

15:35 - 16:15	L 08	Herfried Griengl (Inst. of Org. Chemistry, TU Graz, A) Enantiospecific formation of cyanohydrins using enzymes – preparative and mechanistic aspects.
16:15 - 16:55	L 09	Theo Sonke & Marcel Wubbolts (DSM, Geleen, NL) Biocatalysts: from discovery to application in custom manufacturing.
16:55 - 17:00		Bernard Witholt (Inst. of Biotechnology, ETH, Zurich, CH) Closing remarks
END
Note: This program may be subject to minor changes.

Hollmann & Lutz

Biocatalysts: from discovery to application in custom manufacturing.