People
Dr. Oliver Frick
Department of Solar Materials
Helmholtz Centre for Environmental Research
Kubus, Room 411
Permoserstraße 15
04318 Leipzig
Tel.: +49-341-235 46 88
Fax.: +49-341-235 45 12 86
E-Mail:
Resume
Oliver Frick dedicates his main research interests to microbial physiology and metabolism with a major focus on the physiology of photosynthetically active bacteria and microbial consortia. Of particular interest is the response of metabolic networks to introduced genetic and environmental perturbations. This contributes to a better understanding of interrelations between different cellular processes and is a prerequisite for rational cell engineering approaches for the generation of valuable chemical compounds.
CV / Scientific Career
| since 2014 | Senior research scientist in the Department Solar Materials (headed by Prof. A. Schmid) at the Helmholtz Centre for Environmental Research GmbH - UFZ (Leipzig, Germany). | |
| 2011 - 2014 | Head of Systems Biotechnology Junior Research Group at the Chair of Prof. Andreas Schmid, Laboratory of Chemical Biotechnology (Department of Biochemical & Chemical Engineering, TU Dortmund University, Dortmund, Germany). | |
| 2009 - 2011 | Post-Doctoral Research Fellow at the Chair of Prof. Andreas Schmid, Laboratory of Chemical Biotechnology (Department of Biochemical & Chemical Engineering, TU Dortmund University, Dortmund, Germany). | |
| 2008 - 2009 | Post-Doctoral Research Fellow in the group of Prof. Lars Nielsen at the Australian Institute for Bioengineering and Nanotechnology (AIBN) and representative of the Metabolomics Australia Queensland node at the University of Queensland (Brisbane QLD, Australia). | |
| 2004 - 2007 | Doctoral course (PhD) at the Biochemical Engineering Institute (headed by Prof. E. Heinzle) at Saarland University (Saarbrücken, Germany). Title of the PhD thesis: ‘Regulation of metabolic fluxes in Bacillus subtilis by nutrient conditions – involvement of regulatory proteins’ |
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| 1997 - 2003 | Study of biological sciences at Saarland University (Saarbrücken, Germany) with the major subject Microbiology-Biotechnology and the minor subjects Genetics and Biochemistry. Title of the diploma thesis: ‘Characterization of the yeast Saccharomyces cerevisiae by combined analysis of metabolome and transcriptome’ |
Publications
Peer Reviewed Articles
2017
- Oehling V., Klaassen P., Schmid A. and Frick O. (2017)
Arabinose triggers its own uptake via induction of the arabinose specific Gal2p transporter in an arabinose fermenting Saccharomyces cerevisiae strain.
Submitted
2015
- Köhler K. A. K., Blank L. M., Frick O. and Schmid A. (2015)
D-Xylose assimilation via the Weimberg pathway by solvent tolerant Pseudomonas taiwanensis VLB120.
Environmental Microbiology, 17(1):156-170, DOI-Link
- Rosenthal K., Falke F., Dusny C., Frick O., van den Vlekkert H. and Schmid A. (2015)
An inert microfluidic bioreactor for chemical and biological analysis of a single isolated microbial cell.
Micromachines, 6(12):1836–1855, DOI-Link
- Theodosiou E., Frick O., Bühler B. and Schmid A. (2015)
Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.
Microbial Cell Factories, 14:108, DOI-Link
2013
- Falcioni F., Blank L. M., Frick O., Karau A., Bühler B. and Schmid A. (2013)
Proline availability regulates proline-4-hydroxylase synthesis and substrate uptake in proline-hydroxylating recombinant Escherichia coli.
Applied and Environmental Microbiology, 79(9):3091-3100, DOI-Link
2012
- Dusny C., Fritzsch F. S. O., Frick O. and Schmid A. (2012)
Isolated Microbial Single Cells and Resulting Micropopulations Grow Faster in Controlled Environments.
Applied and Environmental Microbiology, 78(19):7132-7136, DOI-Link
- Fritzsch F. S. O.*, Dusny C.*, Frick O. and Schmid A. (2012)
Single Cell Analysis in Biotechnology, Systems Biology, and Biocatalysis.
Annual Review of Chemical and Biomolecular Engineering, 3:129-155, DOI-Link
* These authors contributed equally to this work.
Oral Presentations
2011
- Frick O. (2011)
Towards single cell systems biotechnology - cultivation and analytics.
Trends in Metabolomics - Analytics and Applications, 19. May 2011, Frankfurt am Main, Germany
Posters
2015
- Grund M., Frick O., Bühler B. and Schmid A. (2015)
Towards quantitative physiology in cyanobacteria by isotopically instationary 13C-metabolic flux analysis .
DECHEMA Summer School Quantitative Biology 2015, 20. - 24. July 2015, Berlin, Germany
- Grund M., Krabbe P., Frick O., Bühler B. and Schmid A. (2015)
Towards quantitative physiology in cyanobacteria.
1st International Solar Fuels Conference (ISF-1), 26. April - 01. May 2015, Uppsala, Sweden
- Grund M., Frick O., Bühler B. and Schmid A. (2015)
Metabolic Engineering of Cyanobacteria as Efficient Industrial Biocatalysts.
UFZ EnergyDays 2015, 24. - 25. February 2015, Leipzig, Germany
2014
- Grund M., Frick O., Bühler B. and Schmid A. (2014)
Metabolic Engineering of Cyanobacteria as Efficient Industrial Biocatalysts.
DECHEMA Summer School Biotransformations 2014, 24. - 27. August 2014, Bad Herrenalb, Germany
- Theodosiou E., Frick O., Bühler B. and Schmid A. (2014)
Metabolic engineering of E. coli for efficient and high yielding trans-4-hydroxy-L-proline production from L-proline.
10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses, 07.-10. September 2014, Lille, France
- Theodosiou E., Frick O., Falcioni F., Bühler B. and Schmid A. (2014)
Metabolic flux analysis unravels the interconnection between cell physiology and biocatalytic activity of E. coli containing recombinant proline-4-hydroxylase.
Systems Biology Course, 02. - 08. March 2014, Innsbruck, Austria
- Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
Analysis of a single-cell: Imprisoned, but feeling well.
5th annual CLIB-graduate cluster retreat, 12. – 14. February 2014, Lünen, Germany
- Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
The Envirostat 3.0: Microfluidic chip development for sampling of metabolites secreted by a single cell.
3rd BioProScale Symposium, 02. - 04. March 2014, Berlin, Germany
2013
- Falcioni F., Theodosiou E., Frick O., Schmid A. and Bühler B. (2013)
Whole-cell biocatalysis for the conversion of L-proline to trans-4-hydroxy-L-proline with high specificity, yield, and productivity.
Biotrans 2013, 21. - 25. July 2013, Manchester, UK
- Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2013)
The Way for Single Cell Analysis: Pick the right, hold it tight, - then do a sight, if it’s bright.
4th annual CLIB-graduate cluster retreat, 13. – 15. February 2013, Lünen, Germany
- Oehling V., Fritzsch F. S. O., Dusny C., Rosenthal K., Kortmann H., Frick O. and Schmid A. (2013)
Single cell analysis of ethanol producing Saccharomyces cerevisiae.
3rd BE-Basic Symposium, 5. - 7. February 2013, Noordwijkerhout, The Netherlands
2012
- Theodosiou E., Frick O., Bühler B. and Schmid A. (2012)
Metabolic engineering of E.coli for the production of trans-4-hydroxy-L-proline.
Metabolic Engineering IX, 3. - 7. June 2012, Biarritz, France
- Dusny C., Fritzsch F. S. O., Rosenthal K., Frick O. and Schmid A. (2012)
Quantitative physiology with isolated single cells and micropopulations in controlled microenvironments employing a picoliter bioreactor.
The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), 28. October – 1. November 2012, Okinawa, Japan
- Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2012)
Fluoreszenz gestützte Analytik von Mikroorganismen im mikrofluidischen Einzelzellreaktor.
ProcessNet-Jahrestagung, 10. - 13. September 2012, Karlsruhe, Germany
- Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2012)
An Overview: Microbioreactors and Analytics for Systems biology on Single Cell Level .
2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
- Fritzsch F. S. O., Oehling V., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2012)
Contactless single cell analysis of industrial relevant bacteria in controlled microenvironments.
2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
- Rosenthal K., Frick O. and Schmid A. (2012)
Single cell analysis of industrial relevant microorganisms.
3rd annual CLIB-graduate cluster retreat, Bergisch-Gladbach, Germany
- Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Frick O. and Schmid A. (2012)
Beyond the bulk: Analysis and cultivation of single yeast and bacteria in precisely controlled extracellular environments (Best poster award).
2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
2011
- Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2011)
Single Cell Analysis in Biotechnology A: An Overview: From defined Microenvironments towards Systems Biology.
Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
- Fritzsch F. S. O., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2011)
Single Cell Analysis in Biotechnology B: The Envirostat 2.0 – A next generation microfluidic platform for single cell analysis in controlled microenvironments.
Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
- Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Oehling V., Frick O., Blank L. M. and Schmid A. (2011)
Single Cell Analysis in Biotechnology C: Time-resolved quantitative physiology of trapped single yeast and bacteria in defined microenvironments.
Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
- Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2011)
Relationship between cell physiology and biocatalytic activity in E. coli expressing proline-4-hydroxylase.
Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
- Hillen M, Frick O., Falcioni F., Schmid A. and Bühler B. (2011)
Metabolic analysis and optimization of a recombinant Escherichia coli as a biocatalyst for the production of trans-4-hydroxy-L-proline from L-proline.
2ND SUMMER SCHOOL Biotransformations, 22. - 25. August 2011, Bad Herrenalb, Germany
2010
- Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
Microbial physiology determines the catalytic efficiency of proline hydroxylation by proline-4-hydroxylase.
BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
- Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
Interrelation between α-ketoglutarate dependent proline hydroxylation and metabolic network operation in recombinant E. coli.
Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, RI, USA